Myxobacteria: Natural pharmaceutical factories

Juana Diez; Javier P. Martinez; Jordi Mestres; Florenz Sasse; Ronald Frank; Andreas Meyerhans

doi:10.1186/1475-2859-11-52

Myxobacteria: Natural pharmaceutical factories

Juana Diez
, Javier P. Martinez
, Jordi Mestres
, Florenz Sasse
, Ronald Frank
, Andreas Meyerhans

Pompeu Fabra University
Helmholtz Centre for Infection Research

Producción científica: Contribución a una revista › ERRATUM

38 Citas (Scopus)

Resumen

Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

Idioma original	Inglés
Número de artículo	52
Publicación	Microbial Cell Factories
Volumen	11
DOI	https://doi.org/10.1186/1475-2859-11-52
Estado	Publicada - 30 abr 2012
Publicado de forma externa	Sí

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ODS 3: Salud y bienestar

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abstract = "Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.",

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AU - Diez, Juana

AU - Martinez, Javier P.

AU - Mestres, Jordi

AU - Sasse, Florenz

AU - Frank, Ronald

AU - Meyerhans, Andreas

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

AB - Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

KW - Chemical space

KW - Drug discovery

KW - Myxobacteria

KW - Natural products

UR - https://www.scopus.com/pages/publications/84862229590

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DO - 10.1186/1475-2859-11-52

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JO - Microbial Cell Factories

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ER -

Myxobacteria: Natural pharmaceutical factories

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