Myxobacteria: Natural pharmaceutical factories

Juana Diez; Javier P. Martinez; Jordi Mestres; Florenz Sasse; Ronald Frank; Andreas Meyerhans

doi:10.1186/1475-2859-11-52

Myxobacteria: Natural pharmaceutical factories

Juana Diez
, Javier P. Martinez
, Jordi Mestres
, Florenz Sasse
, Ronald Frank
, Andreas Meyerhans

Pompeu Fabra University
Helmholtz Centre for Infection Research

Research output: Contribution to journal › ERRATUM

38 Citations (Scopus)

Abstract

Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

Original language	English
Article number	52
Journal	Microbial Cell Factories
Volume	11
DOIs	https://doi.org/10.1186/1475-2859-11-52
Publication status	Published - 30 Apr 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemical space
Drug discovery
Myxobacteria
Natural products

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10.1186/1475-2859-11-52

Cite this

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AU - Diez, Juana

AU - Martinez, Javier P.

AU - Mestres, Jordi

AU - Sasse, Florenz

AU - Frank, Ronald

AU - Meyerhans, Andreas

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

AB - Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

KW - Chemical space

KW - Drug discovery

KW - Myxobacteria

KW - Natural products

UR - https://www.scopus.com/pages/publications/84862229590

U2 - 10.1186/1475-2859-11-52

DO - 10.1186/1475-2859-11-52

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JO - Microbial Cell Factories

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M1 - 52

ER -

Myxobacteria: Natural pharmaceutical factories

Abstract

UN SDGs

Keywords

Access to Document

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