iPHACE: Integrative navigation in pharmacological space

Ricard Garcia-Serna; Oleg Ursu; Tudor I. Oprea; Jordi Mestres

doi:10.1093/bioinformatics/btq061

iPHACE: Integrative navigation in pharmacological space

Ricard Garcia-Serna
, Oleg Ursu
, Tudor I. Oprea
, Jordi Mestres

Municipal Institute for Medical Research Hospital del Mar
University of New Mexico

Research output: Contribution to journal › Scientific article › peer-review

27 Citations (Scopus)

Abstract

Summary: The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment. With this aim, we developed iPHACE, an integrative web-based tool to navigate in the pharmacological space defined by small molecule drugs contained in the IUPHAR-DB, with additional interactions present in PDSP. Extending beyond traditional querying and filtering tools, iPHACE offers a means to extract knowledge from the target profile of drugs as well as from the drug profile of protein targets. Availability: iPHACE is available at http://cgl.imim.es/iphace/ (EU site) and http://agave.health.unm.edu/iphace/(US mirror). Contact: [email protected].

Original language	English
Article number	btq061
Pages (from-to)	985-986
Number of pages	2
Journal	Bioinformatics
Volume	26
Issue number	7
DOIs	https://doi.org/10.1093/bioinformatics/btq061
Publication status	Published - 15 Feb 2010
Externally published	Yes

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title = "iPHACE: Integrative navigation in pharmacological space",

abstract = "Summary: The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment. With this aim, we developed iPHACE, an integrative web-based tool to navigate in the pharmacological space defined by small molecule drugs contained in the IUPHAR-DB, with additional interactions present in PDSP. Extending beyond traditional querying and filtering tools, iPHACE offers a means to extract knowledge from the target profile of drugs as well as from the drug profile of protein targets. Availability: iPHACE is available at http://cgl.imim.es/iphace/ (EU site) and http://agave.health.unm.edu/iphace/(US mirror). Contact: [email protected].",

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AU - Garcia-Serna, Ricard

AU - Ursu, Oleg

AU - Oprea, Tudor I.

AU - Mestres, Jordi

PY - 2010/2/15

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AB - Summary: The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment. With this aim, we developed iPHACE, an integrative web-based tool to navigate in the pharmacological space defined by small molecule drugs contained in the IUPHAR-DB, with additional interactions present in PDSP. Extending beyond traditional querying and filtering tools, iPHACE offers a means to extract knowledge from the target profile of drugs as well as from the drug profile of protein targets. Availability: iPHACE is available at http://cgl.imim.es/iphace/ (EU site) and http://agave.health.unm.edu/iphace/(US mirror). Contact: [email protected].

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iPHACE: Integrative navigation in pharmacological space

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