In Vitro and In Vivo Behaviour of Bioactive Glass Composites Bearing a NSAID

J. A. Méndez; A. González-Corchón; M. Salvado; F. Collía; J. A. De Pedro; B. Levenfeld; M. Fernández; B. Vázquez; J. San Román

In Vitro and In Vivo Behaviour of Bioactive Glass Composites Bearing a NSAID

J. A. Méndez
, A. González-Corchón
, M. Salvado
, F. Collía
, J. A. De Pedro
, B. Levenfeld
, M. Fernández
, B. Vázquez
, J. San Román

ICTP-CSIC
Universidad de Salamanca
Universidad Carlos III de Madrid

Research output: Contribution to journal › Conference article › peer-review

1 Citation (Scopus)

Abstract

Bioactive acrylic formulations based on PMMA, bioactive glasses in the system SiO₂-CaO-Na₂O, and the drug fosfosal, have been effective in providing the formation of an apatite layer on their surface in vitro. The in vivo behaviour studied in the femur of rabbits showed a clear integration between this material and the distal end of the femoral bone shaft after 12 weeks, without a defined structural interface bone-cement. Osseous neoformation was detected by the existence of areas of osteoid around the pellet of cement.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Key Engineering Materials
Volume	254-256
Publication status	Published - 2004
Externally published	Yes
Event	The Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal Duration: 6 Nov 2003 → 9 Nov 2003

Keywords

Bioactive bone cement
Bioactive glass
Fosfosal
Hydroxyapatite
PMMA

Cite this

@article{d2934c080b22486cb84e431cdf0daa09,

title = "In Vitro and In Vivo Behaviour of Bioactive Glass Composites Bearing a NSAID",

abstract = "Bioactive acrylic formulations based on PMMA, bioactive glasses in the system SiO2-CaO-Na2O, and the drug fosfosal, have been effective in providing the formation of an apatite layer on their surface in vitro. The in vivo behaviour studied in the femur of rabbits showed a clear integration between this material and the distal end of the femoral bone shaft after 12 weeks, without a defined structural interface bone-cement. Osseous neoformation was detected by the existence of areas of osteoid around the pellet of cement.",

keywords = "Bioactive bone cement, Bioactive glass, Fosfosal, Hydroxyapatite, PMMA",

author = "M{\'e}ndez, \{J. A.\} and A. Gonz{\'a}lez-Corch{\'o}n and M. Salvado and F. Coll{\'i}a and \{De Pedro\}, \{J. A.\} and B. Levenfeld and M. Fern{\'a}ndez and B. V{\'a}zquez and \{San Rom{\'a}n\}, J.",

year = "2004",

language = "English",

volume = "254-256",

pages = "177--180",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications Ltd",

note = "The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 06-11-2003 Through 09-11-2003",

}

TY - JOUR

T1 - In Vitro and In Vivo Behaviour of Bioactive Glass Composites Bearing a NSAID

AU - Méndez, J. A.

AU - González-Corchón, A.

AU - Salvado, M.

AU - Collía, F.

AU - De Pedro, J. A.

AU - Levenfeld, B.

AU - Fernández, M.

AU - Vázquez, B.

AU - San Román, J.

PY - 2004

Y1 - 2004

N2 - Bioactive acrylic formulations based on PMMA, bioactive glasses in the system SiO2-CaO-Na2O, and the drug fosfosal, have been effective in providing the formation of an apatite layer on their surface in vitro. The in vivo behaviour studied in the femur of rabbits showed a clear integration between this material and the distal end of the femoral bone shaft after 12 weeks, without a defined structural interface bone-cement. Osseous neoformation was detected by the existence of areas of osteoid around the pellet of cement.

AB - Bioactive acrylic formulations based on PMMA, bioactive glasses in the system SiO2-CaO-Na2O, and the drug fosfosal, have been effective in providing the formation of an apatite layer on their surface in vitro. The in vivo behaviour studied in the femur of rabbits showed a clear integration between this material and the distal end of the femoral bone shaft after 12 weeks, without a defined structural interface bone-cement. Osseous neoformation was detected by the existence of areas of osteoid around the pellet of cement.

KW - Bioactive bone cement

KW - Bioactive glass

KW - Fosfosal

KW - Hydroxyapatite

KW - PMMA

UR - https://www.scopus.com/pages/publications/0347028286

M3 - Conference article

AN - SCOPUS:0347028286

SN - 1013-9826

VL - 254-256

SP - 177

EP - 180

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - The Annual Meeting of the International Society for Ceramics in Medicine

Y2 - 6 November 2003 through 9 November 2003

ER -

In Vitro and In Vivo Behaviour of Bioactive Glass Composites Bearing a NSAID

Abstract

Keywords

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