Desing, production and characterization of cytotoxic variants of pancreatic ribonucleases: Study of the molecular bases of the cytotoxic mechanism.

Description of impact

Desing and production of antitumor, antiviral and antimicrobial drugs based on recombinat ribonucleases (targeting RNA). Study of the mechanism involved in the cytotoxic activity: identification of the molecular targets, entry to the cells and other determinats involved in the acquisition of cytotoxic properties. Assesment of the antitumoral activity in model animals .