Myxobacteria: Natural pharmaceutical factories

Juana Diez; Javier P. Martinez; Jordi Mestres; Florenz Sasse; Ronald Frank; Andreas Meyerhans

doi:10.1186/1475-2859-11-52

Myxobacteria: Natural pharmaceutical factories

Juana Diez
, Javier P. Martinez
, Jordi Mestres
, Florenz Sasse
, Ronald Frank
, Andreas Meyerhans

Pompeu Fabra University
Helmholtz Centre for Infection Research

Producció científica: Contribució a revista › ERRATUM

38 Cites (Scopus)

Resum

Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

Idioma original	Anglès
Número d’article	52
Revista	Microbial Cell Factories
Volum	11
DOIs	https://doi.org/10.1186/1475-2859-11-52
Estat de la publicació	Data de publicació - 30 d’abr. 2012
Publicat externament	Sí

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title = "Myxobacteria: Natural pharmaceutical factories",

abstract = "Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.",

keywords = "Chemical space, Drug discovery, Myxobacteria, Natural products",

author = "Juana Diez and Martinez, \{Javier P.\} and Jordi Mestres and Florenz Sasse and Ronald Frank and Andreas Meyerhans",

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doi = "10.1186/1475-2859-11-52",

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journal = "Microbial Cell Factories",

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publisher = "BioMed Central Ltd",

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T2 - Natural pharmaceutical factories

AU - Diez, Juana

AU - Martinez, Javier P.

AU - Mestres, Jordi

AU - Sasse, Florenz

AU - Frank, Ronald

AU - Meyerhans, Andreas

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

AB - Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.

KW - Chemical space

KW - Drug discovery

KW - Myxobacteria

KW - Natural products

UR - https://www.scopus.com/pages/publications/84862229590

U2 - 10.1186/1475-2859-11-52

DO - 10.1186/1475-2859-11-52

M3 - ERRATUM

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JO - Microbial Cell Factories

JF - Microbial Cell Factories

M1 - 52

ER -

Myxobacteria: Natural pharmaceutical factories

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